Direct flights to the Italian city will launch on 12 April.
More than a thousand islanders voted as part of Aurigny's destination survey.
Every Saturday for a month, holidaymakers can fly direct between Guernsey and Genoa.
Chief Commercial Officer at Aurigny, Sudeep Ghai, says the city has much to offer.
'Genoa offers a mix of culture, food, and sun, just in time for Easter.
'We’ve carefully crafted our seasonal schedule this year to offer our community direct connectivity to exciting destinations across Europe while continuing to safeguard the vital lifeline services to the UK that our customers rely on.'
Flights run until 10 May and start from £149.99 one way.
Prime Guernsey seafront location for sale
Woman (20) arrested on suspicion of attempted murder in Guernsey
Last day to register for Guernsey's upcoming by election
New citizen science project observing Guernsey dragonflies and damselflies
Channel Islands music school to hit global stage with Dubai launch
67,000 sickness days across the States of Guernsey last year
The Channel Islands are officially in meteorological drought
Islanders asked for views on body image and masculinity
